Our laboratory studies different aspects of skeletal muscle and cardiovascular physiology, principally focusing on mechanisms of plasma membrane repair, cellular metabolism and calcium homeostasis in normal physiology and how changes in these can contribute to heart failure and various neuromuscular diseases including muscular dystrophy, Membrane repair is a conserved cellular process where intracellular vesicles actively patch membrane disruptions to allow survival of the cell. These studies examine the role of tripartite motif (TRIM) family E3 ubiquitin ligases in these processes and how these can be targeted as therapeutic interventions.