Advisor: Mark Parthun
220 Rightmire Hall
1060 Carmack Road
Columbus, OH 43210
Areas of Expertise
- DNA Replication & Repair
DNA of eukaryotic cells is packaged in a nucleoprotein complex known as chromatin. The fundamental unit of chromatin is the nucleosome, consisting of approx. two turns of DNA wrapped around a protein core of histones, important not only for structural packaging of DNA but also for regulating many cellular processes (transcription, replication, recombination and DNA repair). Proper control of these processes is essential for maintaining cellular growth control.
Our laboratory is focused on the type B histone acetyltransferases, one of which is Histone Acetyltransferase 1 (Hat1) in mice. This class of enzymes is localized to the cytoplasm and specifically acetylates free histones. These enzymes are thought to acetylate newly synthesized histones during chromatin assembly. Upon loss of Hat1, proteomic analysis of mouse embryonic fibroblasts suggests many proteins are increased or depleted on nascent chromatin. My studies are currently interested in characterizing the role of the proteins most depleted on nascent chromatin in an effort to better understand the role of Hat1 and its histone mark in chromatin assembly.
Lovejoy, C.M. and Parthun, M.R., Role of Hat1 During DNA Replication-Coupled Chromatin Assembly (Poster), FOCUS Symposium, Pomerene Hall at The Ohio State University. 3/22/19.
Lovejoy, C.M. and Parthun, M.R., Role of Hat1 During DNA Replication-Coupled Chromatin Assembly (Poster), IGP Symposium, Ohio Union at The Ohio State University. 5/21/19.
3/28/2019-3/29/2019 Guest Lecturer and Lab Instructor, Introduction to Genetics, Ohio Northern University Biology Department
Leadership and Professional Experience:
2019-2020 President, Chromatin and Epigenetics Group Graduate Student Organization, (Ohio State University)