Jack Evans

Jack Evans

Jack Evans

Advisor: Shan-Lu Liu

evans.2381@osu.edu

83 Veterinary Medicine Academic Building
1900 Coffee Rd.
Columbus, OH 43210

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Areas of Expertise

  • Cell Biology
  • Virology

My research focuses on virus-host interactions.  Specifically, I am investigating the restriction of HIV release by the host TIM-proteins and the mechanism of HIV Nef-mediated evasion of these TIM-proteins. During the COVID-19 pandemic, the Liu lab was tapped to develop a sensitive pseudotyped lentivirus based assay for SARS-CoV-2 neutralizing antibodies. I have contributed to this work and will continue investigating the mechanisms of SARS-CoV-2 entry into host cells. 

Publications:
Rizzo, M.J., Evans, J.P., Burt, M., Saunders, C.J., and Johnson, E.C. (2018) Unexpected role of a conserved domain in the first extracellular loop in G protein-coupled receptor trafficking. Biochem. Biophys. Res. Commun. 503, 1919-1926, doi:10.1016/j.bbrc.2018.07.136.

Evans, J.P. and Liu, S.L. (2019) Multifaceted roles of TIM-family proteins in virus-host interactions. Trends in Microbiology. 28, 224-235, doi: 10.1016/j.tim.2019.10.004.
 
Zeng, C., Evans, J.P., Pearson, R., Qu, P., Zheng, Y.M., Robinson, R.T., Hall-Stoodley, L., Yount, J., Pannu, S., Mallampalli, R.K., Saif, L., Oltz, E., Lozanski, G., and Liu, S.L. (2020) Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers and convalescent plasma donors: a cohort study using a rapid and sensitive high-throughput neutralization assay. MedRxiv. doi: 10.1101/2020.08.02.20166819. (Pre-Print)

Poster Presentations:
Evans, JP, Rizzo, M.J., and Johnson, E.C. Analysis of conserved tryptophan residue in Drosophila AKHR using constitutively active mutant variants (Poster). Center for Redox Biology and Medicine Spring 2018 Retreat, Wake Downtown Auditorium, Wake Forest University. 13 April 2018. 

Grants and Fellowships:
2018-2019 Distinguished University Fellowship, The Ohio State University.

2020-2022 Barber Fund, College of Veterinary Medicine, The Ohio State University.

Leadership: 

2019-2020 President, MCDB Graduate Student Organization

 

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