Advisor: Karin Musier-Forsyth
3035 McPherson Laboratory
140 W 18th Ave.
Columbus, OH 43210
Areas of Expertise
- RNA Biology
- BS: Cornell University
Aminoacyl-tRNA synthetases (ARSs) are major components of cellular translational machinery. My research is focused on the function of human glutamyl-prolyl tRNA synthetase (EPRS), a bi-functional ARS, and its relation to human diseases. Specifically, my goal is is to 1) characterize the interaction of EPRS with HIV-1 structural protein Gag and determine its underlying function in viral infection; 2) determine the effect of EPRS point mutations identified in human disease samples on protein functions and cell viability.
Jin, D., & Musier-Forsyth, K. (2019). Role of host tRNAs and aminoacyl-tRNA synthetases in retroviral replication. Journal of Biological Chemistry, 294(14), 5352-5364. doi: 10.1074/jbc.REV118.002957.
Non-canonical Function of Glutamyl-Prolyl-tRNA Synthetase (EPRS) in HIV-1 Infection. Danni Jin, Yiping Zhu, Corine St. Gelais, Nathan Titkemeier, Alice Duchon, Li Wu, Stephen P. Goff, Karin Musier- Forsyth. 43th Annual Meeting on Retroviruses, Cold Spring Harbor NY, 5/21/2018-5/26/2018
Grants and Fellowships:
2018 Travel grant from the Robin C. Burrell Memorial Fund, Dept. of Chemistry and Biochemistry
Leadership and Professional Experience:
2019 Served on OSU Student Organizing Committee for Midwest Virology Symposium 2019
2019 Judge at North Central District Science Day & the Marion Area Science and Engineering Fair (Marion, OH)
2017-2018 Secretary, MCDB Graduate Student Organization
2016-2017 General Member, MCDB MLS Speaker Committee
Awards and Honors:
2019 National Clinical Research Center for Child Health Travel Award (for outstanding oral presentations), 12th International Symposium on Aminoacyl-tRNA Synthetases
2018 2nd place, MCDB 3-Minute Thesis Event