Clathrin-coated structures account for the largest fraction of receptor and macromolecule internalization from the surface of eukaryotic cells. Over the past decades, a multitude of biophysical and biochemical methodologies have been employed to elucidate structural and dynamic properties of clathrin coats. However, fundamental aspects of CME remain controversial due to lack of experimental approaches that merge ultra-structural and dynamic properties of clathrin coats. My lab develops and utilizes innovative experimental and analytical approaches for studying structural and dynamic properties of endocytic clathrin coats in vitro (isolated cells in culture) and in vivo (tissues of multicellular organisms).

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