Stephen Lessnick

Stephen Lessnick

Stephen Lessnick

Professor, Pediatrics

lessnick.1@osu.edu

(614) 355-2633

Children's Hospital
700 Children's Drive
Columbus, OH
43205

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Areas of Expertise

  • Bioinformatics
  • Cancer Biology
  • Gene Expression
  • Molecular Medicine

Education

  • PhD: University of California

My research takes a translational approach to Ewing sarcoma, with the overarching goal of applying basic science discoveries to the clinical care of patients with this disease. We therefore have a significant focus on the basic biology of Ewing sarcoma, including the function of the EWS/FLI oncoprotein as a transcription factor, the associated epigenetic effects mediated by the fusion protein, and the phenotypic consequences mediated by EWS/FLI and its target genes important for the development of this disease.  We use a number of techniques, including high-throughput genomics, molecular biology, and biochemistry, to accomplish these goals.  We strive to translate these findings to patients, by assessing whether new discoveries might serve as critical nodes needed for tumor development.  For example, the lysine specific demethylase 1 (LSD1) enzyme is required for the transcriptional function of EWS/FLI.  We have been studying LSD1 inhibitors as potential therapies for Ewing sarcoma by analyzing the effects of LSD1 blockade on transcription, phenotype, and ultimately tumorigenesis both in vitro and in vivo.  Finally, we also analyze patient specimens as a means to validate our laboratory-based studies; these samples also provide us with new hypotheses to study in the lab.  Together, this philosophy and approach allow us to take a comprehensive approach to understanding this disease, and in doing so, to make an impact on patients with this highly-aggressive pediatric and young-adult cancer.

 

Lessnick Lab Webpage

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