Sanjana Rajan

Sanjana Rajan

Sanjana Rajan

Advisor: Ryan Roberts

rajan.59@osu.edu

Research Building II, WA5108
700 Children’s Drive
Columbus, OH
43205

Google Map

Research:
For a long time, the cells within a tumor were thought to be similar to one another, like a bowl of chocolate chips. However, scientific studies have identified that a patient’s tumor cells are, in fact, highly diverse, more like different colored candies in a bowl. A direct implication of this diversity is that some cancer cells can now survive the selective pressure from chemotherapy, causing patients to have relapsed tumors.

As researchers and clinicians, we need to be able to identify these cells to target them up front along with chemotherapy in order to eliminate resistance. The real question, however, is what are we targeting?
 
Are we targeting a group of cells that were resistant to begin with, prior to treatment, or are we targeting an acquired physiological response that endows some cells with a survival advantage? This is a fundamental question that has remained unanswered for years, a question that I will address in the context of osteosarcoma.
 

Publications:
Ebenezer, A. J., Prasad, K., Rajan, S. & Thangam, E. B. (2018) Silencing of H4R inhibits the production of IL-1β through SAPK/JNK signaling in human mast cells. J. Recept. Signal Transduct. 38, 204 -212. doi: 10.1080/10799893.2018.1468783 (Co-author)

Poster Presentations:
Rajan, S., Gross, AC., Evans, R., Roberts, RD. Signals from lung epithelial cells induce a non-proliferative chemoprotective state in osteosarcoma cells. (Poster presentation) Interdisciplinary Graduate Program Symposium, OSU Ohio Union. May 2019.

Rajan, S., Gross, AC., Evans, R., Roberts, RD. Signals from lung epithelial cells induce a non-proliferative chemoprotective state in osteosarcoma cells. (Poster presentation) OSU Wexner Medical Center, Columbus. April 2019.
 
Rajan, S., Evans, R., Gross, AC., Roberts, RD. Leveraging single cell transcriptional profiles to identify osteosarcoma subsets that mediate resistance to chemotherapy. (Poster presentation) CAS, Columbus. September 2018.
 

Grants and Scholarships:
2019-2021  Pelotonia Fellowship, Pelotonia Fellowship Program, $30,180
2018-2019  Steps for Sarcoma Idea Award, Steps for Sarcoma, $25,000
2016-2017  University Fellowship, The Ohio State University, $69,862

Teaching Experiences:
2017  Graduate Teaching Assistant, BIOCHEM 4511, Department of Biochemistry

Leadership and Professional Experience:
2017-2019  Professional Development Head, MCDB (Columbus)
2018-2019  Center Prepresentative, Research Institute Trainee Association, NCH (Columbus)

Awards:
2019   Elevator Pitch Competition - First Place Center for Childhood Cancers and Blood Disorders
2019   Three Minute Thesis - First Place Molecular Cellular and Developmental Biology Graduate Program