The primary research focus of the Sharma laboratory is to study how pathogens like retroviruses regulate multiple steps of their replication cycle by interfacing with host cell biology. Ongoing research in our lab is characterizing the retrovirus-host interactions in the non-human primate models of HIV-1 infection. In particular, we study the replication of chimeric HIV/SIV viruses (SHIVs) in the macaque model of HIV-1 infection.

Research areas:

• Retrovirus-host interactions
• Innate immune response against retrovirus infection
• Molecular mechanisms of lentiviral restriction in non-human primates
• SHIV/Macaque models of HIV-1 infection
• HIV-1 transmission and pathogenesis