Heather Shive

Heather Shive

Heather Shive

Assistant Professor, Veterinary Biosciences

shive.5@osu.edu

(614) 247-8182

454 VMAB
1900 Coffey Rd
Columbus, OH
43210

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Areas of Expertise

  • Cancer Biology
  • DNA Replication & Repair
  • Gene Expression

Education

  • PhD: University of Maryland
  • DVM: North Carolina State University

Our research focuses on identifying and characterizing genetic and molecular mediators of BRCA2-associated carcinogenesis, and uses the zebrafish model as a unique and powerful in vivo system for these investigations. We have used the brca2-mutant zebrafish model to provide novel insight into the effects of BRCA2 mutation on development, gonadogenesis, and tumorigenesis. We have also identified conserved mechanisms of BRCA2-associated carcinogenesis in zebrafish, such as the collaborative effects of brca2 and tp53 on cancer susceptibility; loss of heterozygosity in zebrafish cancers as a contributor to carcinogenesis; and impact of genotype and sex on tumor ploidy and survival outcome. Our current focus is to identify key events occurring in cancer onset that are linked to heritable BRCA2 mutation. Using both cell-based systems and zebrafish models, we seek to understand mechanisms that enhance or suppress the potential for BRCA2-mutant cells to undergo transformation and initiate cancer development.

Shive Lab Webpage

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