Interested in Cell Biology? Take a look at what MCDB faculty are doing in this area:
Mechanisms underlying heart and skeletal muscle diseases, with a primary focus on the role of RNA-binding proteins in regulating the expression of pathologic genes during stress challenges.
My research interests focus on the intricate structural organization and functionality of striated muscle physiology and pathophysiology. Specifically, we focus on: 1. the intercalated disc proteome and its role in maintaining the synchronous beating of the heart and 2. the role of novel obscurins, a family of cytoskeletal and signaling proteins, in cardiac and skeletal muscle.
Host-pathogen interaction, f ocused on the role of cytosolic NOD-like receptors and their ability to activate inflammatory responses to combat pathogens and the role of caspases in innate immune response to pulmonary pathogens.
Angiogenesis and vasculogenesis; tumor microenvironment including cancer stem cells; preclinical cancer chemotherapy; neural immune cross talk in cancer.
Characterization of connective tissue growth factor: structure-function analysis and role in fibrotic disease.
The mechanism of slow axonal transport.
Steroid hormones signal through proteins that are able to bind DNA and initiate transcriptional programs. These transcription factors are critical mediators of virtually all physiological processes and are often deregulated in diseases such as cancer. The focus of my research is to dissect the molecular mechanisms controlling these factor’s activity with a particular interest in chromatin/epigenetic regulation.
Roles of fringe genes and Notch signaling during mouse development. Analysis of cyclic mRNA_expression during somitogenesis: linking the Notch pathway and the segmentation clock.
Role of Neurotrophins and related molecules in cell growth and differentiation both in physiological and pathological conditions. Mouse modeling of cancer and other human diseases.
Protein secretion and membrane assembly; membrane and lipid biochemistry.
Dr. Davis’ lab focuses on the cellular and molecular basis of muscle contraction and relaxation via understanding how calcium binding proteins/enzymes are appropriately “tuned” kinetically to respond to calcium transients in vitro and in vivo. One of the laboratory goals is to modulate cellular function through the design and engineering of calcium binding proteins.
In our lab, we are interested in understanding how spatial patterns in a cell can arise from small scale interactions between proteins. We use both theoretical and experimental approaches, using zygotes of the nematode worm Caenorhabditis elegans as our model organism.
We are interested in understanding mechanisms leading to formation of exine, the remarkably diverse cell wall of plant pollen grains. By using techniques of genetics, molecular biology, microscopy, and biochemistry, we are studying the biosynthesis, pattern formation, and evolution of this amazing structure.
Genetic, cell biological, and biochemical studies of the protozoan parasite Plasmodium falciparum in an effort to discover novel therapeutics to treat human malaria.
Neural development, regeneration, and survival of cells in the retina. In particular, neural stem cells that are found at the peripheral edge of the retina or those that are derived from the major type of glial cell in the retina, the Müller glia. Investigating the cellular and molecular mechanisms that control the proliferation and differentiation of neural precursors in the developing and mature retina.
Cell cycle regulation of the Mps1 family of protein kinases; centrosome duplication and spindle checkpoint control; mis-regulation of Mps1 and its role in genetic instability and cancer.
Chemokine-mediated breast cancer progression and metastasis; molecular mechanism of chemokine receptor CXCR4/CCR5-mediated pathogenesis during HIV infection; small molecular weight inhibitors for chemokine receptors and characterizing cross-talk between Slit/Robo and chemokine receptor pathways as a novel target for combating breast cancer metastasis and HIV infection.
Role of DNA methylation and microRNAs in liver disease.
Dr. Guo's research focuses on Cancer Biology, Cell Biology, Tumor Metabolism, Oncogenic Signaling, Autophagy, and Lipid Distribution and Trafficking
Dr. Guo's lab is really interdisciplinary with diverse technologies and variable projects involving the areas of cell biology, molecular medicine, virology, biophysics, biotechnology, biochemistry, chemistry, computation, biomedical engineering, single molecular optics, single molecular conductance, single pore sensing, RNA Nanotechnology, nucleic acid chemistry, cancer therapy, drug delivery, viral DNA packaging, and ATPase motors. The lab has been focused on the study of viral DNA packaging motor that is composed of a protein channel driven by six ATPase and geared by six RNA molecules.
Molecular pathogenesis of human T-cell leukemia virus (HTLV); molecular biology of retrovirus replication; T-cell activation/transformation.
Our research goals are to understand how ion channels are precisely localized to control neuronal excitability and how localization and function of ion channels are altered in neurodegenerative diseases.
NF-kappa β regulation of cell growth and differentiation.
Redox factors and heme delivery systems involved in the maturation of chloroplast and mitochondrial c-type cytochromes, assembly of mutimeric complex I in mitochondria.
Eukaryotic cell proliferation; ras protein signaling; RNA pol II transcription.
Intracellular trafficking of RNA and proteins; Nucleus organization; RNA processing.
Role of cell adhesion molecules in the processes of synaptogenesis and circuit assembly in the developing zebrafish nervous system.
Investigation of cell death pathways in Central Nervous System Disorders; delivery of Gene Therapy Vectors to the CNS; identification of Neural Stem Cell Signaling Pathways and Development
Molecular events leading to the formation of tumors of the endocrine glands, and the relationship of these processes to the differentiation of these tissues.
Actin is an abundant eukaryotic protein involved in a variety of vital cellular events including, but not limited to cell migration, cytokinesis, endo- and exocytosis, organelle transport, and muscle contraction. We are interested in deciphering molecular and cellular mechanisms of actin-based processes, their regulation by actin binding proteins and disruption by bacterial and viral pathogens.
Molecular basis of neurodegenerative diseases.
Cell biology of osteoclasts with particular emphasis on differentiation and the cytoskeleton; mechanisms by which kidney tubule cells regulate mRNA levels during and following cellular stresses.
The Lilly lab studies mechanisms of blood vessel formation and smooth muscle differentiation. Our specific interests include endothelial and smooth muscle cell interactions, mechanisms of Notch signaling, and transcriptional control of smooth muscle gene expression.
Focus is on understanding embryonic origins of adult heart disease, with a specific interest in heart valves. Lab uses in vitro and in vivo tools in combination with molecular biology, bioengineering and imaging skills to examine the mechanisms of how heart valves form in the developing embryo, and how alterations in embryogenesis give rise to dysfunctional heart valves after birth.
Professor Liu studies virus-host interactions, in particular how RNA viruses enter host cells and cause pathogenesis in humans and animals. While in the past the Liu lab has been mainly focusing on retroviruses, including HIV, current efforts also include some new human emerging and re-emerging infectious diseases, such as Ebola and Zika. Rotation and research projects include a better understanding the molecular process by which RNA viruses enter host cells or fuse with them, as well as developing effective ways to deliver human gene therapy. The Liu lab also studies some interferon-stimulated genes (ISGs), including IFITM, Viperin and Tetherin, with an ultimate goal of developing effective therapeutic strategies. Another aspect of Liu lab research is viral oncology, with major efforts in elucidating how some viral oncogenes induce oncogenic transformation leading to cancer as well as discovering new tumor viruses that could be associated with human lung and other epithelial cancers
Signal transduction pathways that regulate the cellular responses to extracellular stimuli. Investigate the role of MAP kinase phosphatases in the regulation of inflammatory cytokine biosynthesis in macrophages during bacterial infection. Investigations the basic mechanisms of aging and the molecular mechanisms via which triptolide induces apoptosis in a variety of cancer cells.
Functional analysis of the tumor suppressor genes BRCA1 and BRCA2 in normal and malignant development. Cancer biology. Animal models of human cancer.
We are studying how a circadian (24-hour) clock modulates cellular and molecular processes and chemical and electrical synaptic transmission, and how disruption of this circadian system mediates neuronal degeneration. We are also studying the cellular, subcellular(eg transporters), developmental, and neural network mechanisms that underlie information processing in the brain.
My goal is to develop and apply analytical methods in genomics, epigenomics, and metabolomics to carefully characterize disease, cancer especially, at a molecular level. Please visit my website at u.osu.edu/mathelab for current research and news.
Focus is on elucidating causes of cardiovascular malformations, with the goal of developing novel therapies. We apply a variety of human genetic techniques (linkage, association, sequencing) to identify and characterize candidate genes. Functional consequences are studied in cell based systems. We use genetic and environmental models to examine cardiovascular developmental biology in the mouse.
The research efforts in my laboratory rely upon an integrated scientific approach that is designed to identify the genetic pathways responsible for the ontogenesis and pathogenesis of smooth muscle tissues. The dysregulation of smooth muscle differentiation represe.
Anchoring of Ran signal transduction in plants; nuclear pore and nuclear envelope protein function; genomic analysis of long coiled-coil proteins.
Assembly of viral and host cell RNAs into HIV-1 and other retroviruses; Quality control by aminoacyl-tRNA synthetases and related trans-editing enzymes; Non-canonical functions of aminoacyl-tRNA synthetases and role in human disease.
Molecular genetics of complex diseases.
Our laboratory investigates the epigenetic mechanisms of hematopoietic development and leukemogenesis. We employ genome-wide and targeted profiling of epigenetic marks in combination with functional molecular approaches to elucidate the role of epigenetic mechanisms in normal and malignant blood cells. We also aim to discover predictive epigenetic biomarkers and novel therapeutic targets of disease.
Cell cycle; nuclear migration; fungal development.
Nonnuclear oncogenes, ETS-family transcription factors, and the regulation of transcription during cellular differentiation and malignant transformation.
Regulation of Cell Growth and Oriented Cell Division; Oxidative Stress Response and Cell Death; GTPase signaling pathways.
Chemokine receptor signaling, generation of calcium second messengers, activation of calcium channels and their role in regulating migration of immune cells.
Elucidating the role of microRNAs and epigenetic aberrations in multiple myeloma (MM). Lab is also focused on studying the role of MM microvesicles in cell-cell communication and on preclinical evaluation in experimental therapeutics for clinical trials.
The afferent pathways by which immune activity are transmitted to the central nervous system.
Mouse models of neuromuscular diseases.
Molecular and cellular mechanism of intracellular parasitism/Ehrlichia spp.
The laboratory utilizes mouse models of human cancer to investigate the role of parathyroid hormone-related protein in bone metastasis and cancer-associated hypercalcemia. Metastases are monitored using in vivo bioluminescence of luciferase-transfected tumor cells. Molecular studies are focused on the regulation of PTHrP mRNA stability by transforming growth factors.
Regulation of mRNAstability; pre-mRNA processing and translation initiation; posttranscriptional control by estrogen.
MicroRNA biology, tissue injury and repair, regenerative medicine, nutrition, oxygen and hypoxia, wound healing, stroke and neurodegeneration, myocardial infarction.
My research program will focus on novel molecular mechanisms of exercise to improve metabolic health. This will be broken down into three different aspects; exercise-induced adaptations to white and brown adipose tissue, the effects of parental exercise on the metabolic health of offspring, and the effects of exercise to improve the hypermetabolic response to burn injury.
Air pollution, exercise, and ambient temperature changes and exposures on human health, especially pulmonary and cardiovascular diseases and cancer.
The Tridandapani lab is focused on macrophage biology, specifically examining 1) macrophage role in monoclonal antibody therapy for cancer; 2) macrophage interactions with microbial pathogens. We use immunological, biochmical and molecular biology techniques along with animal models to test our hypotheses.
Our laboratory studies different aspects of skeletal muscle and cardiovascular physiology, principally focusing on mechanisms of plasma membrane repair, cellular metabolism and calcium homeostasis in normal physiology and how changes in these can contribute to heart failure and various neuromuscular diseases inculding muscular dystrophy, Membrane repair is a conserved cellular process where intracellular vesicles actively patch membrane disruptions to allow survival of the cell. These studies examine the role of tripartite motif (TRIM) family E3 ubiquitin ligases in these processes and how these can be targeted as therapeutic interventions.
Post-transcriptional gene regulation in Drosophila; germ cell biology.
Roles of cytoskeletal and signaling proteins in cellular asymmetry and cell division in normal, cancer, and stem cells.
V(D)J recombination; protein binding to recombination signal sequences.
Research focuses on the molecular mechanisms by which immune cells disseminate HIV in order to facilitate the development of more effective interventions against HIV infection and transmission.
Cell signaling; neuronal apoptosis; transgenic mice; myelination; role of small GTPases in brain development; nerve injury.
Objective of first research area is to investigate natural killer (NK) cell innate immune response to tumor cells through understanding signaling pathways, cell activation, cell subsets, and cell development of NK cells. The goal of the project is to perform NK cell-based immunotherapy to treat leukemia, glioblastoma or hepatocellular carcinoma. The second research area is regarding hematopoietic stem cell transplantation (HSCT). This includes stem cell mobilization and HSCT associated complications such as graft-versus-host disease (GVHD) and leukemia relapse.
The functional role of astrocyte potassium and gap junction channels in normal and stroke brain.