Interested in Molecular Neurobiology research? Take a look at what MCDB faculty are doing this area:
The role of acid-sensing ion channels in neuronal signaling.
Elucidation of the underlying causes of motoneuron dysfunction in motoneuron diseases using zebrafish as a model system.
The mechanism of slow axonal transport.
Genetics of motor neuron disorders and the muscular dystrophies.
Cancer biology; regulation of pre-mRNA splicing in normal cellular function and disease.
Neural development, regeneration, and survival of cells in the retina. In particular, neural stem cells that are found at the peripheral edge of the retina or those that are derived from the major type of glial cell in the retina, the Müller glia. Investigating the cellular and molecular mechanisms that control the proliferation and differentiation of neural precursors in the developing and mature retina.
Our research goals are to understand how ion channels are precisely localized to control neuronal excitability and how localization and function of ion channels are altered in neurodegenerative diseases.
Gene therapy for dominant genetic diseases using RNA interference (RNAi), with particular focus on muscular dystrophy and neurodegenerative disease.
Role of cell adhesion molecules in the processes of synaptogenesis and circuit assembly in the developing zebrafish nervous system.
Investigation of cell death pathways in Central Nervous System Disorders; delivery of Gene Therapy Vectors to the CNS; identification of Neural Stem Cell Signaling Pathways and Development.
Molecular basis of neurodegenerative diseases.
My laboratory studies the pathophysiology of multiple sclerosis.
Transmissible Spongiform Encephalopathies (TSEs).
We are studying how a circadian (24-hour) clock modulates cellular and molecular processes and chemical and electrical synaptic transmission, and how disruption of this circadian system mediates neuronal degeneration. We are also studying the cellular, subcellular(eg transporters), developmental, and neural network mechanisms that underlie information processing in the brain.
Research in the Martin lab is focused on the role of glycoyslation in synapse formation and muscular dystrophy. Other studies involve understanding the role of carbohydrates in the development of the brain, and the development of diagnostic and therapeutic reagents for Alzheimer's disease.
Second messenger signaling and transcriptional pathways that regulate circadian timing: Ca2+, CREB and neuronal plasticity: peptidergic modulation of glutamatergic signaling.
The afferent pathways by which immune activity are transmitted to the central nervous system.
My research aims to better understand and treat the maladaptive immune response after spinal cord injury. This is composed of i) the systemic spinal cord injury-induced immune deficiency syndrome (SCI-IDS), ii) consecutive infections and ii) the developing post-traumatic autoimmunity. Both maladaptive neuro-immunological syndromes and their consequences are contributing to the underlying neuropathology and represent a candidate target to improve neurological recovery.
MicroRNA biology, tissue injury and repair, regenerative medicine, nutrition, oxygen and hypoxia, wound healing, stroke and neurodegeneration, myocardial infarction.
Yoon, Sung Ok
Cell signaling; neuronal apoptosis; transgenic mice; myelination; role of small GTPases in brain development; nerve injury.
The functional role of astrocyte potassium and gap junction channels in normal and stroke brain.