MCDB faculty are conducting research in other areas outside of the defined specializations:
Research focuses on the understanding of plant/crop metabolism to increase the production of valuable compounds. The lab uses a dual approach combining metabolomics and fluxomics studies to unravel the biochemistry involved in storage product accumulation and to identify targets for metabolic engineering.
Host-pathogen interaction, f ocused on the role of cytosolic NOD-like receptors and their ability to activate inflammatory responses to combat pathogens and the role of caspases in innate immune response to pulmonary pathogens.
Focus on gene discovery for specific language impairment, autism and related cognitive traits.
Angiogenesis and vasculogenesis; tumor microenvironment including cancer stem cells; preclinical cancer chemotherapy; neural immune cross talk in cancer.
Benson, Jr., Don
Research is focused in natural killer cell immunity against multiple myeloma and other B-cell hematologic malignancies. Our work is primarily translational and concentrated in the development of novel immunotherapeutics for B-cell hematologic malignancies including cytokines, antibodies, and immune modulating agents both in a conventional setting and in the context of blood and marrow transplantation.
The mechanism of slow axonal transport.
Steroid hormones signal through proteins that are able to bind DNA and initiate transcriptional programs. These transcription factors are critical mediators of virtually all physiological processes and are often deregulated in diseases such as cancer. The focus of my research is to dissect the molecular mechanisms controlling these factor’s activity with a particular interest in chromatin/epigenetic regulation.
Dr. Davis’ lab focuses on the cellular and molecular basis of muscle contraction and relaxation via understanding how calcium binding proteins/enzymes are appropriately “tuned” kinetically to respond to calcium transients in vitro and in vivo. One of the laboratory goals is to modulate cellular function through the design and engineering of calcium binding proteins.
We are interested in understanding mechanisms leading to formation of exine, the remarkably diverse cell wall of plant pollen grains. By using techniques of genetics, molecular biology, microscopy, and biochemistry, we are studying the biosynthesis, pattern formation, and evolution of this amazing structure.
Mechanisms involved in cell death during the innate immune response and oncogenic transformation.
Genetic, cell biological, and biochemical studies of the protozoan parasite Plasmodium falciparum in an effort to discover novel therapeutics to treat human malaria.
Chemokine-mediated breast cancer progression and metastasis; molecular mechanism of chemokine receptor CXCR4/CCR5-mediated pathogenesis during HIV infection; small molecular weight inhibitors for chemokine receptors and characterizing cross-talk between Slit/Robo and chemokine receptor pathways as a novel target for combating breast cancer metastasis and HIV infection.
Dr. Guo's lab is really interdisciplinary with diverse technologies and variable projects involving the areas of cell biology, molecular medicine, virology, biophysics, biotechnology, biochemistry, chemistry, computation, biomedical engineering, single molecular optics, single molecular conductance, single pore sensing, RNA Nanotechnology, nucleic acid chemistry, cancer therapy, drug delivery, viral DNA packaging, and ATPase motors. The lab has been focused on the study of viral DNA packaging motor that is composed of a protein channel driven by six ATPase and geared by six RNA molecules.
Eukaryotic gene expression, stress responses, cell death (apoptosis), cell cycle regulation, signal transduction, molecular mechanisms of diseases including cancer, diabetes and liver dysfunction. Experimental systems include cell free system, cell culture, transgenic and knock-out mice models.
The Jackman laboratory utilizes the principles and techniques of mechanistic enzymology and enzyme kinetics to elucidate the molecular mechanisms of tRNA processing enzymes.
Pathogens secrete effector proteins that enhance virulence by functioning inside plant cells. Plants express resistance proteins that can sense effectors and induce an innate immune response. Current research focuses the molecular mechanisms of each of these processes.
We are studying how a circadian (24-hour) clock modulates cellular and molecular processes and chemical and electrical synaptic transmission, and how disruption of this circadian system mediates neuronal degeneration. We are also studying the cellular, subcellular(eg transporters), developmental, and neural network mechanisms that underlie information processing in the brain.
My goal is to develop and apply analytical methods in genomics, epigenomics, and metabolomics to carefully characterize disease, cancer especially, at a molecular level. Please visit my website at u.osu.edu/mathelab for current research and news.
Focus is on elucidating causes of cardiovascular malformations, with the goal of developing novel therapies. We apply a variety of human genetic techniques (linkage, association, sequencing) to identify and characterize candidate genes. Functional consequences are studied in cell based systems. We use genetic and environmental models to examine cardiovascular developmental biology in the mouse.
Immune modulation by measles virus and vaccination in the presence of maternal antibodies.
Regulation of Cell Growth and Oriented Cell Division; Oxidative Stress Response and Cell Death; GTPase signaling pathways.
Chemokine receptor signaling, generation of calcium second messengers, activation of calcium channels and their role in regulating migration of immune cells.
My lab is primarily interested in dissecting the signal transduction processes involved in a) immune-complex clearance by macrophages, and the associated inflammation, and b) the inflammatory response to bacterial lipopolysaccharide.
Our Group's fundamental research interest is to understand how does eukaryotic cell integrate various extracellular and intrinsic signals/cues to dictate cellular fate (cell proliferation, death, growth and differentiation). We focus on the interplay between cell metabolic programs and cell signaling cascades in patho-physiological contexts such germ cell development, tumorigenesis and immunes response. Notably, these are three examples that the fate change of a single cell (a germ cell, clonal expanding transformed cell and lymphocyte) will change the fate of whole organism. Our experimental models, each one of these has unique biological and technical features, include mouse model of human tumors and autoimmune disease (accessible for genetic and pharmacological modulations), frog oocytes (with defined cell cycle stage and accessible for direct intracellular injection of biological material), primary cells: MEFs, lymphocytes and macrophages (with defined genetic background and accessible genetic modulation and responsive to various patho-physiological stimulations).
Our current research program covers two important areas in bioprocessing and bioengineering. The first one is animal cell culture and tissue engineering; the second one is bioprocessing for value-added products.