Join us for MLS Seminar featuring Dr. Anna Kashina, Professor of Biomedical Sciences at the University of Pennsylvania! The title of her talk is Actin regulation before, during, and after translation.
The goal of Dr. Kashina's research is to investigate the physiological role of a previously uncharacterized posttranslational modification, protein arginylation. Knockout of the enzyme responsible for arginylation, ATE1, results embryonic lethality in mice and multiple defects related to heart development and blood vessel remodeling (angiogenesis). Dr. Kashina's recent work showed that arginylation regulates many proteins involved in cytoskeleton, cell motility, signaling, and metabolism, and uncovered some mechanisms of this regulation.
Dr. Kashina's current studies are focused on three major directions: (1) identification of the ATE1 protein targets and studying the effect of arginylation on their properties and functions; (2) studies of the structure and molecular properties of the mouse ATE1 enzymes; and (3) discovering the mechanisms and pathways that leads to the global physiological effects of protein arginylation.
