The Blaser Laboratory is interested in understanding how the hematopoietic microenvironment regulates the clonal evolution of hematopoietic stem cells (HSCs) under homeostatic conditions, during development, and in the initiation of myeloid neoplasia.  We focus on how stress response, inflammatory, and regenerative pathways alter HSC clonal diversity and lineage commitment.  We use the zebrafish model system and incorporate chemical genetics, genetic barcoding, lineage tracing, live cell imaging, and single cell analyses into our studies.  Our work may shed light on how the clonal diversity of the blood system changes over the course of a lifetime and help to understand why this can lead to devastating blood cancers.

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