Dr. Breuer’s translational research focus is on the advancement of Tissue Engineered Vascular Grafts (TEVG).  TEVG’s are constructed by seeding bone marrow derived mononuclear cells onto a biodegradable tubular scaffold, and then autologously implanting them.  The seeded scaffold provides an environment conducive for building new tissue. Upon scaffold degradation, a new blood vessel has formed which resembles a native vessel both structurally and functionally. His basic science research focuses on enhancing TEVG design by exploring the cellular and molecular mechanisms underlying this vascular “neotissue” formation using both large and small animal models.  Currently, we are working on a second generation TEVG human clinical trial that was steered by our animal model work.  Fellows and Residents training with Dr. Breuer will obtain extensive training in basic science principals and methods ranging from animal models to molecular biology.