Interferons (IFNs) play a major role in the establishment of an antiviral and antiproliferative state, when left unchecked IFNs fuel autoinflammatory and autoimmune diseases. My lab is interested in understanding the unique and distinct biological functions of cell intrinsic IFNs and the bifurcation of IFN signaling pathways into canonical (antiviral and inflammatory) and non-canonical (tissue reparative) signaling cascades. We interrogate whether cell state and identity contribute to the induction of either the canonical or non-canonical signaling arms and the contribution of these signaling event to the balance between protective/deleterious responses.