My research focuses on oligodendroglial biology and heterogeneity within contexts of inflammation and aging. We use experimental autoimmune encephalomyelitis as well as toxin-mediated models to induce demyelination for investigation of transcriptional, maturational and remyelination responses by oligodendroglia. We are also interested in how aging impacts oligodendroglial in an inflammatory environment and are conducting similar experiments on aged mice. The aim of our research plan is to investigate pathways that promote or inhibit oligodendroglial homeostatic function and survival with the ultimate goal of finding targetable pathways for promoting remyelination and repair in multiple sclerosis. Our lab uses a variety of techniques including immunology (T cell culture, adoptive transfer, immunization, flow cytometry), neuroscience/glial biology (brain and spinal cord immunohistochemistry, RNAscope, advanced microscopy, electron microscopy, oligodendrocyte culture) and molecular techniques (single cell RNA sequencing, crispr/cas9 gene editing).