My laboratory studies the role of post-transcriptional and post-translational modifications of tRNA and host proteins induced by respiratory pathogens to better understand the regulation of the proteome and the pathways that lead to ARDS with the goal of developing novel therapeutics. We hypothesize that infection leads to changes in the production and function of immunomodulatory proteins both through alterations in translation and by post-translational modifications. By understanding the pathways that are dysregulated during infection we can identify new targets for therapeutic intervention. Three main focuses in my lab: 1) Examining the subcellular proteome in response viral infection. 2) Examining how tRNA alters the inflammatory response and pathogen infection. 3) Examining how ubiquitination alters pathogen infection.