With a Ph.D. degree in computational science and 12 years’ research experience in bioinformatics, I view myself as a well-trained bioinformatics researcher and computational modeler of biological systems. Through independent investigation and collaborative studies with numerous biologists, I have developed a strong and long-term interest in (1) understanding of how functional machinery encoded in a genome/metagenome; (2) elucidation of the metabolic systems and their regulatory mechanisms in a cell; and (3) development of enabling computational techniques in support of the above scientific studies. One of my current research projects aims to examine the construction of cell type-specific gene co-regulation signatures based on single cell transcriptomics data in order to develop a computational model that tracks how genes are expressed in specific cell types and help scientists unravel how diseases progress and evade treatment.