I am a translational scientist who specializes in developing strategies for personalized therapy for lymphoid malignancies. I was trained as a human geneticist, and completed my post-doctoral fellowship in B-cell Lymphoma at the University of Texas MD Anderson Cancer Center in Houston.

My research interests include indolent and aggressive B-cell Non-Hodgkin’s lymphomas and multiple myeloma. The focus of my laboratory is to understand the role of tumor microenvironment in the progression of B-cell lymphomas. Our group has identified a subpopulation of tumor cells capable of initiating the bulk tumor, and we are trying to identify the therapeutic target unique to these initiating cells. I am also interested in understanding how non-coding RNA regulates epigenetic marks and contributes to drug resistance in lymphoma. Our group aims to translate the findings to the clinic through drug development.

I currently serve as an assistant professor in the Department of Internal Medicine. My work has been published in numerous hematologic journals such as Leukemia, Blood, Hematologica, British Journal of Hematology, Molecular Cancer Research and Journal of Cell Science, and I have presented my research at more than a dozen national and international conferences. Additionally, I have received multiple awards, including the Endowed Fellow Award for Excellence in lymphoma.

The James is on the cutting edge of cancer research, and every day new therapeutic approaches are being tested and utilized in our hospital. It’s truly exciting to be part of a multidisciplinary team that’s making big strides toward our shared goal of a cancer-free world.

Sehgal Lab Website