Areas of Expertise

Cell Biology

Education

PhD: Pierre and Marie Curie University

My lab studies the molecular mechanisms underlying host-pathogen interactions using Listeria monocytogenes as a model facultative intracellular pathogen.

Specific projects are to:

(1) Establish the L. monocytogenes intracellular life cycle in various mammalian cell types, including human primary placental cells and professional phagocytic cells.

(2) Determine the molecular basis and outcomes of host-cell signaling in response to listeriolysin O, the major virulence factor of L. monocytogenes and a member of the cholesterol-dependent cytolysin (CDC) toxins.

(3) Elucidate the mechanisms underlying the anti-toxin and immunomodulatory activities of antimicrobial peptides that belong to the defensin family.

People Filters:

Cell Biology