Most axons in the central nervous system (CNS) are wrapped with compact layers of myelin sheaths to ensure the rapid transmission of neuronal signals over long distances. As myelin thickness and sheath length profoundly affect conduction velocity, myelination is also crucial to the precise control of spatiotemporal activity patterns in the CNS. Our research focuses on deciphering the cellular and molecular mechanisms controlling activity-dependent myelination in the CNS during postnatal development and myelin repair after CNS trauma and diseases. We are particularly interested in studying the physiology of oligodendrocyte precursor cells and the biophysical properties of neuron-oligodendrocyte lineage cell interaction, and how this interaction initiates downstream cellular and molecular events leading to myelin formation. My lab employs a multi-disciplinary approach combing viral gene delivery, optogenetic and chemogenetic approaches, and advanced imaging techniques, together with in vivo multi-channel recording and ex vivo patch-clamp techniques and behavioral assessment.