The longstanding goal of our lab is to elucidate the function of RNA molecules in gene expression and genome maintenance. Our most recent emphasis is on piRNAs, fascinating small RNA species that defend genome against invasive nucleic acid. The piRNA pathway is essential for germline development and fertility in all animals. Using model system such as C. elegans and non-model organisms, we are interested in understanding the molecular mechanisms of piRNA-directed genome defense and endogenous gene regulation.

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