Dr. Theisen has spent her career studying pharmacological modulation of chromatin regulators in pediatric cancer, with a specific focus on Ewing sarcoma. Her laboratory focuses on how context defines different roles for chromatin complexes, with an emphasis on LSD1-containing complexes. The laboratory aims to understand how specific functions of chromatin complexes interact with unique mechanisms driving pediatric cancers with the long-term goal of building a strong preclinical rationale for novel therapeutic regimens with epigenetic targeted agents. The Theisen lab uses a suite of techniques including molecular biology, biochemical, structural, genomic, proteomic, and translational approaches, exposing students to interdisciplinary problem solving.

Theisen Lab Webpage