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Ambro van Hoof

Ambro van Hoof

Ambro van Hoof

Contact Information

Professor, Department of Molecular Genetics

Email
Email Ambro van Hoof vanhoof.3@osu.edu

Education

  • BS, Agricultural Sciences, Agricultural University Wageningen
  • PhD, Genetics, Michigan State University

All life forms must maintain a homeostatic gene expression program, which is achieved at many different steps in gene expression, including by the maturation, modification and degradation of specific mRNAs and ncRNAs. Many evolutionarily conserved RNA processing enzymes mediate these key post-transcriptional events, with important roles for endo and exoribonucleases. A number of inherited diseases are caused by mutations in endo- or exoribonuclease genes or RNA modification genes, further underscoring their importance for human health. Eukaryotes use exonucleases for the degradation of most cellular mRNAs and for the 5’ and 3’ end processing of many different ncRNAs. In addition, endonucleases target specific mRNAs as an initiating step in mRNA degradation and other endonucleases process ncRNAs. The van Hoof lab uses yeast as a model eukaryote for the functional characterization of ribonucleases and RNA modification enzymes.

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