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Tim McKinsey is a Professor of Medicine-Cadiology at the University of Colorado Anschutz Medical Campus. His presentation is titled, "Regulation of Cardiometabolic Signaling by an Unusual Post-Translational Modification".
Dr. McKinsey's research focuses on understanding the signaling and gene regulatory mechanisms that control heart failure and associated disorders. Particularly, the role of epigenetics in regulating the pathological cardiac hypertrophy and fibrosis that is associated with heart failure. Nuclear DNA is wound around proteins called histones to form chromatin, and post-translational modification of histones represents one epigenetic mechanism for altering gene expression. Among the enzymes that target histones are histone deacetylases (HDACs), histone acetyltransferases (HATs) and histone methyltransferases. He uses molecular biology, biochemistry and pharmacology to address the roles of these and other epigenetic modifiers in the control of gene expression in the heart, and extend his findings to surgical, transgenic and gene knockout models of heart failure. His animal model studies involve echocardiographic and catheter-based measurements of heart function.
