The long-term goals of the Tranter lab are to increase our understanding of the molecular mechanisms that drive cardiometabolic diseases. Ongoing projects in the lab are focused on post-transcriptional gene regulation by the RNA binding protein Human antigen R (HuR) in the setting of (1) the pathological progression of left ventricular hypertrophy and cardiac fibrosis leading to heart failure, (2) the mechanisms of calcium-dependent thermogenic metabolism in brown adipocytes, and (3) adipose tissue-mediated endocrine effects on cardiac physiology.