Ubiquitination plays a critical role in the regulation of protein stability, enzyme activity, protein-protein interaction, and protein cellular localization. The ubiquitin-proteasome system is the major pathway of non-lysosomal intracellular protein degradation andcontrols pro- and anti-inflammatory responses by modulating immune regulatory signal protein turnover.  Protein ubiquitination can be reversed by deubiquitinating enzymes (DUBs).My research interest is to investigate the role of the ubiquitin-mediated protein stability in the pathogenesis of acute lung injury and sepsis. My laboratory research focuses on the molecular regulation of innate immunity, lung endothelial inflammation and barrier integrity.