Studies in the Hund lab span cardiac cell biology and electrophysiology to computational biology and mathematical modeling to murine models of cardiac arrhythmia (in vivo and ex vivo) and heart failure. The focus of the lab is to discover novel pathways for regulation of cardiac excitability with the overall goal of uncovering new therapeutic strategies for human patients suffering from life-threatening electrical rhythm disturbances (arrhythmias). In this vein, a major interest of the lab has been how local signaling domains for the multifunctional calmodulin kinase II (CaMKII) are organized in cardiomyocytes motivated by the strong link between dysregulation in CaMKII signaling, arrhythmias and disease. This effort has identified an important role for the cytoskeletal protein betaIV-spectrin in organizing local signaling domains in cardiac myocytes and fibroblasts.